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1-22 WEIGHT LOSS IN PATIENTS WITH
ALZHEIMER’S DISEASE
After adjustment for age and sex, weight loss was greater
in subjects with Alzheimer’s than in those without.
(Body mass index decreased by an average of 0.5 per year
vs 0.14). The weight loss was substantially greater than
that associated with cancer and congestive heart failure.
BMJ January 18, 1997; 314: 178-79 1-22 WEIGHT LOSS IN PATIENTS WITH
ALZHEIMER’S DISEASE
Weight loss among older
people, often due to cancer and heart disease, has been
associated with increased disability and mortality,
Alzheimer’s disease may be an important source of
weight loss.
This prospective, population based study collected data
during 5 annual clinical evaluations of persons over age
65. After adjustment for age and sex, weight loss was
greater in subjects with Alzheimer’s than in those
without. (Body mass index decreased by an average of 0.5
per year vs 0.14). The weight loss was substantially
greater than that associated with cancer and congestive
heart failure.
The mechanisms linking Alzheimer’s with weight loss
are uncertain. In this study, many subjects had mild
disease. The magnitude of weight loss did not support the
idea that weight loss is confined to those with severe
disease. The behavioral problems associated with advanced
disease (agitation and pacing) do not fully explain
weight loss. Pathological changes in the hypothalamus
have been described which may affect centers regulating
food intake and metabolic processes.
BMJ January 18, 1997; 314:
178-79 Original study, first author from Rush Institute
on Aging, Chicago, IL
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